For the third time in the last seven seasons the Gunners have been paired in the knockout stage with Barcelona and must travel to Camp Nou to face the reigning European champions in the second leg of their last-16 tie – having lost 6-3 and 4-3 on aggregate on the previous two occasions.
Chelsea, meanwhile, have even more recent history with their opponents in the first knockout round because they have faced Paris Saint-Germain in each of the last two campaigns.
Blaise Matuidi of Paris Saint-Germain (left) battles Nemanja Matic of Chelsea for a header during their 2015 International Champions Cup match in Charlotte, North Carolina (Getty Images)
In 2013-14 it was the Blues who came out on top as a 2-0 second-leg success at Stamford Bridge sent them through on away goals, but it was the reverse scenario last term as a 2-2 draw in west London was enough for the French champions as the tie finished 3-3 on aggregate.
As far as the remaining English contingent is concerned, Manchester City have certainly received the most favourable draw in terms of opposition as they will take on Dynamo Kiev although clearly they have the most difficult trip as regards travel.
In a mouthwatering last-16 draw, another heavyweight contest will see Juventus host Bayern Munich in a repeat of the 2012-13 quarter-final which the German side won 4-0 on aggregate on their way to lifting the trophy at Wembley against their compatriots Borussia Dortmund.
The two Madrid clubs should also feel reasonably happy with the way the draw has treated them because Real take on Roma, while Atletico face PSV Eindhoven whose four points claimed against Manchester United during the group stage put paid to the Red Devils’ hopes of progressing.
Two lower-profile ties will also offer opportunities to a couple of comparative outsiders of joining the big guns at the quarter-final stage.
Belgian champions Gent have made it through to the knockout stage at the first attempt and will take on Wolfsburg, while Benfica and Zenit St Petersburg resume rivalry from last season’s group stage in which the Russian club, managed by Andre Villas-Boas, completed the double over the team from the manager’s home country of Portugal.